Impact of SGLT2 inhibitors on cardiovascular disease

Authors: Hana Rosolová
Authors‘ workplace: Centrum preventivní kardiologie, II. interní klinika LF UK a FN Plzeň-Bory
Published in: AtheroRev 2022; 7(2): 82-84
Category: Reviews


Sodium-glucose transporter 2 inhibitors (SGLT2i) or gliflozines are new antidiabetic drugs, which have lots of non-glucose effects; those effects are influential in the reduction of fatal and non-fatal atherosclerotic cardiovascular disease, of hospitalization for heart failure and of all-cause death. The recent metaanalysis of ten prospective randomized clinical studies with SGLT2i and CVD – REAL data from 10 million patients with type 2 diabetes are presented. Gliflozines belong to the basic drugs for the prevention and treatment of heart failure with reduced ejection fraction in patients with and also without diabetes. Nephroprotective effects of gliflozines could include them among the drugs for patients with chronic renal diseases. Glilflozines exceed diabetology and become important drugs for cardiologists, nephrologists and internists too.


cardiorenal syndrome – type 2 diabetes mellitus – heart failure – inhibitors SGLT2 – atherosclerotic cardiovascular disease


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Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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