Evinacumab in the treatment of homozygous familial hypercholesterolemia: data from real-world clinical practice and case report
Authors:
Vladimír Bláha
Authors‘ workplace:
III. interní gerontometabolická klinika LF UK a FN Hradec Králové
Published in:
AtheroRev 2025; 10(2): 111-115
Category:
Reviews
Overview
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic disorder characterized by biallelic mutations in genes regulating the activity of the low-density lipoprotein receptor. Patients with HoFH have significantly elevated LDL-cholesterol (LDL-C) concentrations and are at high risk of premature development of atherosclerotic cardiovascular disease despite combined lipid-lowering therapy. Evinacumab, a fully humanized monoclonal antibody against angiopoietin-like protein 3 (ANGPTL3), represents a new therapeutic option. This article summarizes the mechanism of action, clinical evidence, and practical aspects of administering evinacumab in patients with HoFH based on data from real world evidence (RWE).
Keywords:
Cholesterol – evinacumab – data from real world evidence (RWE) – homozygous familial hypercholesterolemia
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Angiology Diabetology Internal medicine Cardiology General practitioner for adultsArticle was published in
Athero Review
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