Bempedoic acid – a new drug to lower LDL-cholesterol level

Authors: Vladimír Soška 1,2;  Ondřej Kyselák 1,3
Authors‘ workplace: Oddělení klinické biochemie FN U sv. Anny v Brně 1;  II. interní klinika LF MU a FN U sv. Anny v Brně 2;  Katedra laboratorních metod LF MU, Brno 3
Published in: AtheroRev 2022; 7(3): 147-151
Category: Reviews


Lowering LDL-cholesterol is a key step in reducing the risk of atherosclerotic cardiovascular diseases. Statins are the mainstay of therapy, to which ezetimibe may be added in combination, and PCSK9 inhibitors may also be used in some patients meeting the indication criteria. In the near future, the portfolio of hypolipidemics may be expanded to include bempedoic acid. Bempedoic acid suppresses cholesterol synthesis by inhibiting the enzymatic activity of ATP-citrate lyase, which catalyses the initial step of cholesterol synthesis. Phase III clinical trials have demonstrated the safety of this drug and its efficacy in lowering LDL-cholesterol in statin-intolerant patients, patients on maximally tolerated statin doses, as well as its very good efficacy when combined with ezetimibe. The effect of bempedoic acid therapy on the frequency of atherosclerotic cardiovascular events is to be demonstrated in the CLEAR Outcome clinical trial.


Metabolism – Cholesterol – bempedoic acid – LDL-cholesterol – CLEAR Outcome clinical trial


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