LDL-cholesterol – the main risk factor for atherosclerosis


Authors: Branislav Vohnout 1;  Andrea Havranová 2
Authors‘ workplace: Ústav výživy, FO a ZOŠ a Koordinačné centrum pre familiárne hyperlipoproteinémie, Slovenská zdravotnícka univerzita v Bratislave 1;  Ústav experimentálnej endokrinológie – Biomedicínske centrum SAV, Bratislava 2
Published in: AtheroRev 2016; 1(2): 88-92
Category: Reviews

Overview

LDL-cholesterol is one of the main risk factors for atherosclerosis. A large number of studies at the bunk and molecular level have described mechanisms whereby it participates in the initiation and development of atherosclerotic lesions. Epidemiological studies have proven the relationship between LDL-C and the risk of cardiovascular diseases. Genetic studies have shown that congenital increased LDL-C levels lead to an increased cardiovascular risk, while genetically determined lowered LDL-C levels reduce the risk. The causal role of LDL-C has been finally confirmed by the results of many clinical trials that have demonstrated the effect of LDL-C reduction on the cardiovascular risk in patients in primary as well as secondary prevention, and the effect was attained through various mechanisms of LDL-C reduction.

Key words:
LDL-cholesterol – atherosclerosis – cardiovascular diseases


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Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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