PCSK9 inhibitors in the management of patients with high cardiovascular risk – effective treatment to reach

Authors: Ľubomíra Fábryová
Authors‘ workplace: Metabol KLINIK s. r. o., Ambulancia pre diabetológiu, poruchy látkovej premeny a výživy ;  Špecializovaná lipidologická ambulancia, MED PED centrum, Bratislava
Published in: AtheroRev 2016; 1(1): 42-48
Category: Reviews


First-line therapy in secondary prevention and also in primary prevention (in keeping with lifestyle management) are statins with wide range of evidence. The current standards for the prevention of cardio-cerebrovascular diseases emphasize the importance of achieving target levels for LDL-cholesterol. Despite everything statins in clinical practice can’t meet all the goals. It is therefore no wonder that in the lipid-lowering agents still evolve new medication. The latest promise for high-risk patients (with high or very high cardiovascular risk, with homozygous or heterozygous familial hypercholesterolaemia, intolerant of statins or higher doses of statins) are human monoclonal antibodies against PCSK 9 (proprotein convertase subtilisin/kexin type 9). The results of clinical trials from large-scale programs are groundbreaking. Their importance is comparable to the results of 4S study with simvastatin, which was the first in 1994 demonstrated the benefit of statins in secondary prevention. In the near future we will have in clinical practice available alirocumab (Praluent) and evolocumab (Repatha). Despite all this enthusiasm, however, we have to wait for the results of long term studies with morbidity-mortality endpoints (ODYSSEY- OUTCOMES and FOURIER).

Key words:
alirocumab – evolocumab – ODYSSEY – PCSK9-i – PROFICIO


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Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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