Hypolipidemic treatment improves the prognosis of diabetics. Why do we use it so modestly?

Authors: Richard Češka 1;  Jiří Šilar 2
Authors‘ workplace: Centrum preventivní kardiologie, III. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a VFN v Praze 1;  Institut biostatistiky a analýz, s. r. o. 2
Published in: AtheroRev 2021; 6(2): 67-72
Category: Reviews


Currently, the pandemic of non-communicable diseases - type 2 diabetes mellitus (T2DM), hyperlipoproteinemia and dyslipidemia (HLP and DLP) and cardiovascular diseases (CVD) - significantly threatens the health of the population worldwide. The treatment of HLP/DLP and in particular the treatment affecting the levels of LDL-cholesterol (LDL-C) has the potential to improve the prognosis of patients with DM2T and CVD. High-intensity statin therapy is necessary to achieve a reduction in LDL-C levels of at least 50% of the baseline values. Yet even an easily available treatment, such as the combination of a statin and ezetimibe, has not been in use. Because of that, a Prospective Observational Project, named ADVOKÁT Study, was conducted in 2019 and 2020 to assess the benefits of pharmacological intervention with hypolipidemics (statin, ezetimibe) in patients with T2DM. The aim of this observational project was to intensify the treatment of dyslipidemia according to the ESC/EAS recommendations (from 2017). The results of the ADVOKÁT study are summarized in the article.


ADVOKAT study – ezetimibe – hypolipidemics – statins


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Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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