ASCOT Legacy: the first long-term monitoring of the effect of antihypertensive treatment combined with statin on mortality

Authors: Michal Vrablík
Authors‘ workplace: Centrum preventivní kardiologie, III. interní klinika – klinika endokrinologie a metabolismu 1. LF UK a VFN v Praze
Published in: AtheroRev 2020; 5(1): 43-45
Category: clinical studies

  1. Dahlof B, Sever PS, Poulter NR et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005; 366(9489): 895–906. Dostupné z DOI: <–6736(05)67185–1>.
  2. Gupta A, Mackay J, Whitehouse A et al. Long-term mortality after blood pressure-lowering and lipid-lowering treatment in patients with hypertension in the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) Legacy study: 16-year follow-up results of a randomised factorial trial. Lancet 2018; 392(10153): 1127–1137. Dostupné z DOI: <–6736(18)31776–8>.
  3. Margolis KL, Davis BR, Baimbridge C et al. Long-term follow-up of moderately hypercholesterolemic hypertensive patients following randomization to pravastatin vs usual care: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT). J Clin Hypertens 2013; 15(8): 542–554. Dostupné z DOI: <>.
  4. Kostis WJ, Moreyra AE, Cheng JQ et al. Continuation of mortality reduction after the end of randomized therapy in clinical trials of lipid-lowering therapy. J Clin Lipidol 2011; 5(2): 97–104. Dostupné z DOI: <>.
  5. Ford I, Murray H, McCowan C et al. Long term safety and efficacy of lowering LDL-cholesterol with statin therapy: 20-year follow up of West of Scotland Coronary Prevention Study. Circulation 2016; 133(11): 1073–1080. Dostupné z DOI: <>.
  6. Hague WE, Simes J, Kirby A et al. Long-term effectiveness and safety of pravastatin in patients with coronary heart disease: 16 years of follow-up of the LIPID Study. Circulation 2016: 133(19): 1851–1860. Dostupné z DOI: <>
Angiology Diabetology Internal medicine Cardiology General practitioner for adults
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